Washington University in St. Louis


Spencer Lake

Assistant Professor
Professor Lake joined Washington University in St. Louis in 2012. Previously, he worked as a postdoctoral fellow and supervisor of the Tissue Mechanics Laboratory in the Department of Biomedical Engineering at the University of Minnesota.
Professor Lake’s research focuses on soft tissue biomechanics, with an emphasis on orthopaedic tissues, such as tendon and ligament. His research uses a multiscale experimental and computational approach to evaluate the in vivo loading environment, tissue properties, and microstructural structure-function relationships of tissues that function in complex physiologic environments.
Studies conducted by Dr. Lake's research group in the Musculoskeletal Soft Tissue Laboratory aim to enhance fundamental understanding of healthy tissue properties, elucidate changes that occur in (and mechanisms responsible for) injury/disease, and provide guidelines for improved treatment/replacement strategies. While focused primarily on tendon and ligament of the upper extremity (i.e., shoulder and elbow), these studies also have broad applicability towards understanding properties and relationships of many different native and engineered soft tissues.
Selected Publications
Lake SP, Barocas VH: Mechanics and kinematics of soft tissue under indentation are determined by the degree of initial collagen fiber alignment. Journal of the Mechanical Behavior of Biomedical Materials, DOI:10.1016/j.jmbbm.2012.03.017.
Lake SP, Hadi MF, Lai VK, Barocas VH: Mechanics of a fiber network within a non-fibrillar matrix: model and comparison with collagen-agarose co-gels.  Annals of Biomedical Engineering, DOI:10.1007/s10439-012-0584-6.
Lake SP, Cortes DH, Kadlowec JA, Soslowsky LJ, Elliott DM: Evaluation of affine fiber kinematics in human supraspinatus tendon using quantitative projection plot analysis.  Biomechanics and Modeling in Mechanobiology, 11(1-2):197-205, 2012.
Lake SP, Barocas VH: Mechanical and structural contribution of non-fibrillar extracellular matrix in uniaxial tension: a collagen-agarose co-gel model.  Annals of Biomedical Engineering, 39(7):1891-1903, 2011.
Lake SP, Miller KS, Elliott DM, Soslowsky LJ: Tensile properties and fiber alignment of human supraspinatus tendon in the transverse direction demonstrate inhomogeneity, nonlinearity and regional isotropy.  Journal of Biomechanics, 43(4):727-732, 2010.
Contact Spencer Lake
Address 1 Brookings Drive
Campus Box 1185
City/St/Zip St. Louis, MO 63130
Jolley Hall, Room 205
Phone (314) 935-3161
Fax (314) 935-4014
Email lake.s@seas.wustl.edu
Other Appt. Biomedical Engineering & Orthopaedic Surgery

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PhD, University of Pennsylvania, 2009
BS, University of Utah, 2003
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