Professor Lake joined Washington University in St. Louis in 2012. Previously, he worked as a postdoctoral fellow and supervisor of the Tissue Mechanics Laboratory in the Department of Biomedical Engineering at the University of Minnesota. His doctoral research was conducted in the McKay Orthopaedic Research Laboratory at the University of Pennsylvania, and his undergraduate degree is in Bioengineering from the University of Utah.
Professor Lake’s research focuses on soft tissue biomechanics, with an emphasis on orthopaedic tissues, such as tendon and ligament. His research uses a multiscale experimental and computational approach to evaluate the in vivo loading environment, tissue properties, and microstructural structure-function relationships of tissues that function in complex physiologic environments.
Studies conducted by Dr. Lake's research group in the Musculoskeletal Soft Tissue Laboratory
aim to enhance fundamental understanding of healthy tissue properties, elucidate changes that occur in (and mechanisms responsible for) injury/disease, and provide guidelines for improved treatment/replacement strategies. While focused primarily on tendon and ligament of the upper extremity (i.e., shoulder and elbow), these studies also have broad applicability towards understanding properties and relationships of many different native and engineered soft tissues.
York T, Kahan L, Lake SP, Gruev V: Real-time high-resolution measurement of collagen alignment in dynamically loaded soft tissue. Journal of Biomedical Optics, 19(6):66011, 2014.
Deeken CR, Thompson Jr. DM, Castile RM, Lake SP: Biaxial analysis of synthetic scaffolds for hernia repair demonstrates variability in mechanical anisotropy, non-linearity and hysteresis. Journal of the Mechanical Behavior of Biomedical Materials, 38C:6-16, 2014.
Fang F, Sawhney AS, Lake SP: Different regions of bovine deep flexor tendon exhibit distinct elastic, but not viscous, mechanical properties under both compression and shear loading. Journal of Biomechanics, 47:2869-2877, 2014.
York T, Powell SB, Gao S, Kahan L, Charanya T, Saha D, Roberts NW, Cronin TW, Marshall J, Achilefu S, Lake SP, Raman B, Gruev V: Bio-inspired polarization imaging sensors: from circuits and optics to signal processing algorithms and biomedical applications. Proceedings of IEEE, 102(10):1450-1469, 2014.
Lake SP, Ray S, Zihni A, Thompson Jr. DM, Gluckstein J, Deeken CR: Pore size and pore shape – but not mesh density – alter the mechanical strength of tissue ingrowth into synthetic mesh materials in a porcine model of ventral hernia repair. Journal of the Mechanical Behavior of Biomedical Materials, 42:186-197, 2015.
Skelley NW, Castile RM, York T, Gruev V, Lake SP, Brophy RH: Differences in the microstructural properties of the anteromedial and posterolateral bundles of the anterior cruciate ligament. American Journal of Sports Medicine. In press, 2015