Tae Seok Moon became a professor in the Department of Energy, Environmental & Chemical Engineering at Washington University in St. Louis in July 2012.
Professor Moon completed his postdoctoral fellowship in the Voigt Group, in the Department of Biological Engineering & SynBio Center at Massachusetts Institute of Technology and jointly, in the Department of Pharmaceutical Chemistry at University of California-San Francisco.
Professor Moon’s research goals are directed toward creating programmable cells that process multiple input signals and produce desirable outputs for real-world applications. Specifically, he aims to build synthetic gene circuits in order to control and improve metabolic pathways for the production of biomass-based chemicals and drugs.
His postdoctoral research at MIT and University of California-San Francisco provided him with expertise in the design and construction of genetic circuits. As a graduate student at MIT, he learned how to construct and optimize novel metabolic pathways to produce biochemicals that can replace oil-based chemicals. Combining his research experiences with more than five years experience in the biotechnology industry, he envisions his career as transforming biology research from an “observation” approach to a “synthesis-based engineering” activity to address energy, environment and health issues.
TS Moon, C Lou, A Tamsir, BC Stanton and CA Boigt. Genetic Programs Constructed from Layered Logic Gates in Single Cells, Nature, 491, 249-253 (2012)
TS Moon, EJ Clarke, ES Groban, A Tamsir, RM Clark, M Eames, T Kortemme and CA Voigt. Construction of a genetic multiplexer to toggle between chemosensory pathways in Escherichia coli, J. Mol. Biol. 406, 215-227 (2011)
TS Moon, JE Dueber, E Shiue and KJ Prather. Use of Modular, Synthetic Scaffolds for Improved Production of Glucaric Acid in Engineered E. coli, Metab. Eng. 12, 298-305 (2010)
JE Dueber, GC Wu, GR Malmirchegini, TS Moon, CJ Petzold, AV Ullal, KJ Prather and JD Keasling. Synthetic Protein Scaffolds Provide Modular Control over Metabolic Flux, Nat. Biotechnol. 27, 753-759 (2009)