Jonathan R. Silva joined the Department of Biomedical Engineering in July 2012. As a postdoctoral fellow at the Washington University School of Medicine, Professor Silva received the prestigious Burroughs Wellcome Fund Career Award at the Scientific Interface (CASI), which is given to scientists with backgrounds in physics, mathematics, computer science and engineering who want to explore the new frontier of biology.
Professor Silva’s doctoral studies were conducted at the Washington University in St. Louis School of Engineering & Applied Science, where he developed a new type of multi-scale cardiac action potential models that incorporate detailed descriptions of ion channel molecular motions.
Professor Silva studies how perturbations to molecular motions propagate across time and spatial scales to affect the bioelectric systems.
His team is currently focused on the cardiac sodium channel, which initiates cardiac excitation and contraction. By studying these channels using simultaneous fluorescence and ionic current recording, the consequences of genetic mutations and drug treatments can be understood at the molecular level. These results can then be incorporated into detailed computer models to understand their electrophysiological consequences at the organ level.
Voltage Sensor Movements Describe Slow Inactivation of NaV Channels I: Wild Type”, JR Silva and Goldstein SAN, Journal of General Physiology. 141:309-321.
"Voltage Sensor Movements Describe Slow Inactivation of NaV Channels II: L689I Mutants”, JR Silva and Goldstein SAN, Journal of General Physiology. 141:323-334.
“A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential”, JR Silva, et al. Proceedings of the National Academy of Sciences. 106(27):11102-11106.
“Multi-scale electrophysiology modeling: from atom to organ”, JR Silva, Y Rudy. Journal of General Physiology. 135(6):575.