Seminar: “A Paradigm for Functional Tissue Engineering of Articular Cartilage”

Apr 28, 2016
2:45 PM
3:45 PM
Brauer Hall, Room 12

Dr. Clark T. Hung will present. Faculty, students, and the general public are invited. A reception will follow.


Articular cartilage is the specialized connective tissue that covers the ends of the bones that comprise our diarthrodial joints (e.g., knee and hip), and serves a critical load bearing and lubrication function. Absent of blood vessels, cartilage exhibits a poor intrinsic healing capacity after injury. The aim of our laboratory has been to engineer clinically-relevant articular cartilage grafts for repair of damaged and diseased joints. In this effort, several strategies have been employed to promote development of mechanically functional tissue including applied dynamic loading bioreactors and growth factor optimization. In addition to surviving the demanding physical environment, engineered cartilage grafts implanted in pathologic joints must often survive a harsh chemical environment. To address the latter, we have explored strategies to precondition developing cartilage constructs to proinflammatory cytokines, as well as for co-delivery of cells and dexamethasone-laden polymer carriers in engineered cartilage. While these complementary research thrusts were first developed using bovine cells, our team has made significant strides toward translation to cells of a large preclinical animal model (canine), and more recently to human cells.


Dr. Clark T. Hung graduated in 1990 with his BS in Bioengineering from Brown University and 1995 with his PhD in Bioengineering from the University of Pennsylvania. He joined the Department of Biomedical Engineering at Columbia University as an Assistant Professor in 1997 and became a full Professor in 2009. Dr. Hung has been pursuing multidisciplinary research using state-of-the-art biological and engineering tools to perform studies to investigate physical effects (e.g., cell deformation, fluid flow effects, osmotic pressure) on cells and tissues, and the incorporation of these forces in strategies to develop functional cartilage substitutes. An understanding of the effects of physical forces on cells is important in the development of effective tissue replacements that mimic or restore normal tissue structure-function in orthopaedic and other load-bearing tissues of the body. Such studies may lead to strategies aimed at alleviating the most prevalent and chronic problems afflicting the musculoskeletal system such as arthritis, and problems related to sports and occupational injuries. His research has been funded by agencies including the National Institutes of Health, National Science Foundation, Department of Defense, and The Musculoskeletal Transplant Foundation. His work has been published in 150 full-length manuscripts and 14 book chapters. Dr. Hung is a fellow of the American Institute for Medical & Biological Engineering (AIMBE, 2009) and the American Society of Mechanical Engineers (ASME, 2010) and is a recipient of awards including the Negma-Lerards Award in Mechanobiology of Chondrocyte and Cartilage, Marshall Urist Award for Excellence in Tissue Regenerative Medicine from the Orthopedic Research Society, and Kim Award for Faculty Involvement- SEAS. Dr. Hung serves as the Editor-in-Chief of Orthopaedic Research & Reviews (Dove Press open access), Deputy Editor of Journal of Orthopaedic Research, and past Associate Editor of the ASME Journal of Biomechanical Engineering. He currently serves as a standing committee member on the NIH/CSR Skeletal Biology Structure and Regeneration (SBSR) study section (2012-2016).

Organizer / Host: Laura Barker, (314) 935-7096