Room 012, Brauer Hall
Naren Vyavahare, PhD
Hunter Endowed Chair
You Are as Old as Your Elastin: Therapies to Extend Human Life
Functional elastic fibers are an essential component of connective tissues. In healthy individuals, elastic fibers have a half-life of 70 years or more, and they rarely remodel in adults. Irreversible elastic fiber degradation is the unassailable hallmark of diseases such as aortic aneurysms, atherosclerosis, peripheral arterial disease, arteriosclerosis, and lung emphysema and is exacerbated by the inflammatory process inherent to these conditions. Elastin degradation products (EDPs) are also known chemokines for inflammatory cells and therefore contribute to a vicious cycle of disease amplification. Functional elastic fiber development is also important for developing tissue-engineered products. Our ongoing inquiry into site-specific therapies is now set to challenge existing paradigms, shape new translational opportunities, and establish effective treatment options to address pathological elastin degradation. We have identified ways to not only halt disease-related elastin degradation but to repair these crucial elastic fibers and thus initiate a reversal of many cardiovascular- and lung-related disorders. This talk will provide some insights into these nano-medicine therapies.
Dr. Vyavahare is a Director of NIH funded South Carolina Bioengineering Center of Regeneration and Formation of Tissues (SC BioCRAFT). Dr. Vyavahare’s research is published in over 160+ journal publications and conference proceedings, and seven book chapters; additionally, Dr. Vyavahare holds 15 International and US Patents. Some of the patents are now licensed to companies that he helped to start to develop products. He has graduated 14 Ph.D. students and 21 MS students as a principal advisor. Dr. Vyavahare attracted ~$30M NIH research funding at Clemson over the last 19 years. Dr. Vyavahare is the recipient of many awards including; McQueen Quattlebaum Faculty Excellence Award, Faculty mentoring award, and Alumni award for outstanding achievement in research, Clemson University. He is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE). Before joining Clemson in 1999, Dr. Vyavahare served as a Research Assistant Professor at the University of Pennsylvania School of Medicine and the University of Michigan.
Organizer / Host: Co-hosted with IMSE