Room 012, Brauer Hall
Song Hu, PhD
University of Virginia
Multi-parametric Photoacoustic Microscopy: Auscultation of Hemodynamics and Energy Metabolism at the Microscopic Level
Capitalizing on the optical absorption of blood hemoglobin, photoacoustic microscopy (PAM) is ideally suited for label-free imaging of the microvasculature, which plays an essential and indispensable role in supplying oxygen to biological tissues and maintaining metabolic activity in vivo. In this talk, Dr. Hu will present their latest progress on the technical development and biomedical application of PAM. Integrating innovations in instrumentation and data analysis, multi-parametric PAM developed in Dr. Hu's laboratory enables—for the very first time—comprehensive and quantitative characterization of the microvascular structure (diameter, tortuosity and density), mechanical property (resistance, wall shear stress, reactivity and permeability), hemodynamics (blood perfusion, oxygenation and flow), and tissue oxygen extraction and metabolism, all at the microscopic level. This enabling technology has opened up unprecedented opportunities in brain, cardiovascular, cancer, and regenerative medicine research.
Song Hu received his B.S. and M.S. degrees in Electronic Engineering from Tsinghua University and his Ph.D. degree in Biomedical Engineering from Washington University in St. Louis, in 2002, 2005 and 2010, respectively. After that, Dr. Hu continued his research with Dr. Lihong Wang as a postdoctoral associate until starting his own laboratory at the University of Virginia in 2013, where he is currently an Assistant Professor of Biomedical Engineering and a Faculty Member of the Neuroscience Graduate Program, Robert M. Berne Cardiovascular Research Center, and Emily Couric Cancer Center. Dr. Hu pioneers the development of photoacoustic microscopy (PAM) and its applications in neuroscience, cardiovascular biology, cancer, and regenerative medicine. In particular, his laboratory has developed multi-parametric PAM for simultaneous label-free imaging of microvascular blood perfusion, oxygenation and flow at multiple tissue/organ sites in vivo and head-restrained PAM for high-resolution imaging of cerebral hemodynamics and oxygen metabolism in awake behaving rodents. To date, Dr. Hu has published over 60 peer-reviewed articles in journals including Science, Nature (cover story), Nature Neuroscience, and Proceedings of the National Academy of Sciences, and has delivered over 40 invited talks including a Neurotechnologies plenary talk at Photonics West 2018 and a President’s Symposium keynote talk at Annual Microcirculatory Society Meeting 2018. His publications, including the 4th and 6th most cited articles in the Journal of Biomedical Optics since 2009 and the 5th most cited article in Optics Letters since 2007, have accumulated over 5,300 citations (h-index: 27). Dr. Hu serves on the editorial board of Neurophotonics, Photoacoustics, and Scientific Reports, and is a recipient of the Ralph E. Powe Junior Faculty Enhancement Award (2014), American Heart Association National Scientist Development Award (2015), and National Science Foundation Faculty Early Career Development (NSF CAREER) Award (2018).
Organizer / Host: Lori Setton