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Imaging Science Seminar: Designing Targeting Nanoparticals for MRI and PET to Detect Kidney Microstructure and Function

Oct 12
8:40 AM
9:30 AM
Room 0120 Green Hall Rodin Auditorium

Chronic kidney disease (CKD) affects roughly 15% of the adult population worldwide, and roughly. The progression of CKD to end-stage renal disease will generally require patients to undergo dialysis or eventually transplant.  CKD is not detected in its early through conventional serum or urinary markers because of the kidney’s unique ability to compensate for the loss of nephrons, the individual functional units of the kidney.

This talk will focus on new high-resolution imaging techniques my lab and our partners have developed to 1) Detect early microstructural changes in the kidney to facilitate early diagnosis, 2) Develop new tools for transplant evaluation to facilitate better matching between the donor and recipient, and 3) Translate these early technologies to clinical use through radiological imaging. I will discuss magnetic nanoparticle synthesis and approaches to make the MRI sensitive to specific microstructural features such as individual nephrons, and new 3D analysis tools to systematically perform “virtual histopathology” at the micrometer-scale in intact organs. I will also discuss new measurements of single-nephron physiology made possible by MRI, and will touch on pathways to translation and commercialization of these tools.