Professor Lew and his students build advanced imaging systems to study biological and chemical systems at the nanoscale, leveraging innovations in applied optics, signal and image processing, design optimization, and physical chemistry. Their advanced nanoscopes (microscopes with nanometer resolution) visualize the activity of individual molecular machines inside and outside living cells. Examples of new technologies developed in the Lew Lab include 1) using tiny fluorescent molecules as sensors that can detect amyloid proteins, 2) designing new "lenses" to create imaging systems that can visualize how molecules move and tumble, and 3) new imaging software that minimizes artifacts in super-resolution images.
Matthew Lew joined the faculty at Washington University in St. Louis in July 2015. Before arriving in St. Louis, he was a postdoctoral fellow in the de la Zerda Group in Structural Biology at the Stanford University School of Medicine. He earned his PhD in Electrical Engineering working in the laboratory of W. E. Moerner, a WashU alumnus and co-recipient of the Nobel Prize in Chemistry 2014 for "the development of super-resolved fluorescence microscopy."
Professor Lew is a recipient of a 2017 NSF CAREER Award for his project entitled "CAREER: Nanoscale sensing and imaging suing computational single-molecule nanoscopy." In 2016, Professor Lew was given the Hiruma/Wagner Award at the 16th Conference of Peace through Mind/Brain Science. He has also received a Second Place Poster Award at the Gordon Research Conference "Single-Molecule Approaches to Biology" and a PicoQuant Young Investigator Award at SPIE Photonics West. At Stanford, he was a National Science Foundation Graduate Research Fellow, a 3Com Corporation Stanford Graduate Fellow, and a Tau Beta Pi Fellow.
Professor Lew is a member the Optical Society, the American Chemical Society, Tau Beta Pi, and the American Association for the Advancement of Science. He was co-president of the Stanford Optical Society, a student chapter of OSA and SPIE, in 2013-14 and chair of the Stanford University Photonics Retreat in 2013.