Fred Saigh Distinguished Professor of Engineering
Mathematical modeling of cardiac ion channels, cells and tissue to study cardiac excitation and arrhythmias across scales, noninvasive electrocardiographic imaging (ECGI) for the study, diagnosis and treatment of clinical cardiac arrhythmias in patients
Rhythm disorders of the heart lead to over 400,000 cases of sudden death annually in the U.S. alone. Yoram Rudy's research aims at understanding the mechanisms that underlie normal and abnormal rhythms of the heart at various levels, from the molecular and cellular to the whole heart. Through development of detailed mathematical models of ion channels biophysics and electrophysiology, and of cardiac cells and tissue, the Rudy Lab is investigating arrhythmia mechanisms. The cell models have been used worldwide for research, teaching and training. Professor Rudy has also developed a novel noninvasive imaging modality (Electrocardiographic Imaging, ECGI) for diagnosis and guided therapy of cardiac arrhythmias. ECGI is used to study mechanisms of clinical arrhythmias (e.g. atrial fibrillation, ventricular tachycardia, heart failure) in patients. Their premise in the Rudy Lab is that an integrated approach to the study of mechanisms at all levels of the cardiac system, from cell to bedside, and the development of novel diagnostic and therapeutic tools will lead to successful strategies for prevention and treatment of cardiac arrhythmias and sudden death.
Professor Rudy is currently the director of the interdisciplinary Cardiac Bioelectricity and Arrhythmia Center
(CBAC), which includes 39 faculty members.
Professor Rudy came to Washington University in St. Louis in 2004 from Case Western Reserve University, where he had been a member of the faculty and director of the Cardiac Bioelectricity Research and Training Center since 1980.
He has also served as a visiting professor in various universities worldwide, including Oxford, Columbia, Cornell, Johns Hopkins, Bern, Nagoya, Maastricht, Stanford and Technion and delivered many keynote addresses at international scientific meetings.
Professor Rudy published over 200 scientific articles. He graduated 30 doctoral students, who continue to pursue careers in academic research and medicine and in the biomedical industry.
Professor Rudy is a member of the National Academy of Engineering. He is the recipient of numerous awards, among which are: the NIH Merit Award, the Biomedical Engineering Society Distinguished Lectureship Award, the Astor Visiting Professorship at Oxford, the Heart Rhythm Society Distinguished Scientist Award, Case Western Reserve University Distinguished Alumni Award and the Hein Wellens Distinguished Professor in Cardiology at Maastricht University. He also served as President of the Cardiac Electrophysiology Society from 2006-2008.