Wagenseil receives grant from The Marfan Foundation

Jessica Wagenseil, associate professor of mechanical engineering, has received a two-year, $100,000 grant from The Marfan Foundation to study arterial tortuosity and aneurysms.

Jessica Wagenseil

She plans to determine whether arterial tortuosity, a rare condition in which some of the major arteries are twisted, can be used to predict outcomes in mice with aortic disease. In addition, she will study whether the twisting is affected by treatment with captopril, an giotensin-converting enzyme (ACE) inhibitor used to treat hypertension and congestive heart failure. Marfan syndrome is a genetic disorder that affects the body's connective tissue and can cause an aneurysm in the aorta, the main blood vessel that carries blood away from the heart to the rest of the body.