EducationPhD, Washington University in St. Louis, 2008
MS, Case Western Reserve University, 2004
BS, Johns Hopkins University, 2000
Creating better ways to treat cardiac arrhythmia
Cardiac Arrhythmia, Molecular Imaging, Engineered Cardiomyocytes, Computational Models, Extended Reality
Jonathan R. Silva applies computational and biophysical methods to improve arrhythmia therapies. Current projects include development of advanced imaging protocols to inform precision anti-arrhythmic therapies.
Professor Silva joined the Department of Biomedical Engineering at Washington University in St. Louis in July 2012 after receiving the Burroughs Wellcome Fund Career Award at the Scientific Interface (CASI).
Professor Silva’s laboratory has created novel algorithms that predict whether patients will respond to class I anti-arrhythmic molecules. These predictions are based on machine learning approaches that leverage a deep understanding of drug interaction biophysics. His group also developed software to provide a holographic display to physicians who perform catheter ablations for arrhythmia. This software was recently tested in humans, and the results showed that physician accuracy was significantly improved with the display. A company that he co-founded, SentiAR Inc, is commercializing the technology.