A submarine can inadvertently reveal its location because of cavitation, a condition that creates bubbles underwater that burst, then emit sound waves that can be detected by sonar. A team of biomedical engineers at Washington University in St. Louis plans to use the same concept to detect cavitation in human brains that may contribute to blast-induced traumatic brain injury (bTBI).

Hong Chen, associate professor of biomedical engineering in the McKelvey School of Engineering and of radiation oncology at the School of Medicine, plans to develop wearable passive sonar for the brain to detect cavitation with a three-year, $750,000 grant from the Office of Naval Research. These wearable sensors could provide direct evidence of shock wave-induced cavitation in the human brain during exposure to blasts. The data gathered could provide insight into the risk of brain injury caused by cavitation and assist with diagnosis and treatment of blast-induced traumatic brain injury, which has become an all-too-common injury among U.S. military members.  

In addition to developing the sensors, Chen and her team plan to collaborate with Mehdi Kiani, associate professor of electrical engineering at Pennsylvania State University, to develop low-power electronics to acquire and process detected signals.

The Defense and Veterans Brain Injury Center reported nearly 414,000 traumatic brain injuries among U.S. service members worldwide between 2000 and late 2019. Chen said modern body armor can protect warfighters against shrapnel from explosive blasts but cannot prevent shockwave-induced blast-induced traumatic brain injury.

“Shockwave-induced microcavitation is gaining increasing support as one of the key mechanisms for bTBI,” she said. “However, we lack a noninvasive cavitation detection technique for reliable microcavitation detection in the brain. This has been the major roadblock for investigating the microcavitation mechanism for bTBI.” 

The McKelvey School of Engineering at Washington University in St. Louis promotes independent inquiry and education with an emphasis on scientific excellence, innovation and collaboration without boundaries. McKelvey Engineering has top-ranked research and graduate programs across departments, particularly in biomedical engineering, environmental engineering and computing, and has one of the most selective undergraduate programs in the country. With 165 full-time faculty, 1,420 undergraduate students, 1,614 graduate students and 21,000 living alumni, we are working to solve some of society’s greatest challenges; to prepare students to become leaders and innovate throughout their careers; and to be a catalyst of economic development for the St. Louis region and beyond.

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